Abstract
This manuscript shows that ACN can be an excellent choice for the coupling of hindered amino acids as illustrated by the coupling of Fmoc-amino acids on free amino acids anchored on a BAL synthesis. Furthermore, ACN can be a good alternative for solid-phase peptide synthesis in the absence of DMF (washings, removal of Fmoc, and coupling).
2009 European Peptide Society and John Wiley & Sons, Ltd.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetonitriles / chemistry*
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Amino Acids / chemistry
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Fluorenes / chemistry
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Peptides / chemical synthesis*
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Polyethylene Glycols / chemistry*
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Polystyrenes / chemistry*
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Solvents
Substances
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Acetonitriles
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Amino Acids
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Fluorenes
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N(alpha)-fluorenylmethyloxycarbonylamino acids
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Peptides
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Polystyrenes
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Solvents
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aminomethyl-ChemMatrix resin
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polyethylene glycol-polystyrene
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Polyethylene Glycols
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acetonitrile