Solid-phase peptide synthesis using acetonitrile as a solvent in combination with PEG-based resins

J Pept Sci. 2009 Oct;15(10):629-33. doi: 10.1002/psc.1158.

Abstract

This manuscript shows that ACN can be an excellent choice for the coupling of hindered amino acids as illustrated by the coupling of Fmoc-amino acids on free amino acids anchored on a BAL synthesis. Furthermore, ACN can be a good alternative for solid-phase peptide synthesis in the absence of DMF (washings, removal of Fmoc, and coupling).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetonitriles / chemistry*
  • Amino Acids / chemistry
  • Fluorenes / chemistry
  • Peptides / chemical synthesis*
  • Polyethylene Glycols / chemistry*
  • Polystyrenes / chemistry*
  • Solvents

Substances

  • Acetonitriles
  • Amino Acids
  • Fluorenes
  • N(alpha)-fluorenylmethyloxycarbonylamino acids
  • Peptides
  • Polystyrenes
  • Solvents
  • aminomethyl-ChemMatrix resin
  • polyethylene glycol-polystyrene
  • Polyethylene Glycols
  • acetonitrile