Ligophorus saladensis n. sp. (Monogenea: Dactylogyridae) is described from the gills of the grey mullet Mugil platanus Günther collected in Samborombón Bay, Argentina. The new species differs from L. mugilinus Euzet & Suriano, 1977, L. mediterraneus Sarabeev, Balbuena & Euzet, 2005 and L. huitermpe Fernandez, 1987 by the morphology of the accessory piece of the male copulatory organ and mean values derived from measurements of the sclerotised hard-parts. This is the second report of monogeneans on M. platanus in the Southwestern Atlantic Ocean region and the first description of a species of Ligophorus Euzet & Suriano, 1977 from M. platanus. Some aspects of the speciation and host-specificity of Ligophorus spp. are discussed.