Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity

J Inorg Biochem. 2009 Sep;103(9):1196-203. doi: 10.1016/j.jinorgbio.2009.05.017. Epub 2009 Jun 11.

Abstract

The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a-2k) in good yields. Subsequent reaction of these ligands with copper(II) acetate yielded Cu(II) complexes (3a-3k) and some were characterised using X-ray crystallography. All of the free ligands and their metal complexes were tested for their anti-Candida activity. A number of the ligands and complexes exhibited anti-Candida activity comparable to that of the commercially available antifungal drugs, ketoconazole and Amphotericin B.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Antifungal Agents / chemistry*
  • Antifungal Agents / pharmacology
  • Candida albicans / drug effects*
  • Chelating Agents / chemical synthesis
  • Chelating Agents / chemistry*
  • Chelating Agents / pharmacology
  • Copper / chemistry*
  • Coumarins / chemistry*
  • Crystallography, X-Ray
  • Drug Design
  • Ligands
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Models, Molecular
  • Molecular Structure
  • Organometallic Compounds / chemical synthesis
  • Organometallic Compounds / chemistry*
  • Organometallic Compounds / toxicity
  • Schiff Bases / chemical synthesis
  • Schiff Bases / chemistry
  • Schiff Bases / pharmacology
  • Spectrophotometry
  • Transition Temperature

Substances

  • Aldehydes
  • Antifungal Agents
  • Chelating Agents
  • Coumarins
  • Ligands
  • Organometallic Compounds
  • Schiff Bases
  • Copper
  • 7-amino-4-methylcoumarin