Klebsiella pneumoniae clinical isolate coproducing SHV-2a, DHA-1, QnrB4, and AAC(6')-Ib-cr determinants in France

Stéphane Corvec; Lise Crémet; Nathalie Caroff; Sandie Dauvergne; Ronan Le Floch; Alain Reynaud; Didier Lepelletier; Pascale Bémer

doi:10.1016/j.diagmicrobio.2009.04.001

Klebsiella pneumoniae clinical isolate coproducing SHV-2a, DHA-1, QnrB4, and AAC(6')-Ib-cr determinants in France

Diagn Microbiol Infect Dis. 2009 Aug;64(4):462-3. doi: 10.1016/j.diagmicrobio.2009.04.001.

Authors

Stéphane Corvec¹, Lise Crémet, Nathalie Caroff, Sandie Dauvergne, Ronan Le Floch, Alain Reynaud, Didier Lepelletier, Pascale Bémer

Affiliation

¹ Service de Bactériologie-Hygiène Hospitalière, CHU de Nantes, 9 quai Moncousu, 44093 Nantes Cedex 01, France. stephane.corvec@chu-nantes.fr

PMID: 19631103
DOI: 10.1016/j.diagmicrobio.2009.04.001

Abstract

We report on a Klebsiella pneumoniae clinical isolate coproducing bla(DHA-1), bla(SHV-2a), qnrB4, and aac(6')-Ib-cr genes. Molecular analysis demonstrated the presence of this combination on the same large plasmid. Despite a negative result for extended-spectrum beta-lactamase (ESBL) by Vitek2(R) system (bioMérieux, Marcy-l'Etoile, France), an ESBL was detected by a double-disk test. Phenotypic techniques and molecular analysis are key approaches to determine coresistance.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Resistance, Bacterial*
France
Genes, Bacterial*
Humans
Klebsiella Infections / microbiology*
Klebsiella pneumoniae / drug effects*
Klebsiella pneumoniae / genetics*
Klebsiella pneumoniae / isolation & purification
Male
Microbial Sensitivity Tests / methods
Plasmids
Young Adult