Carbolithiation of conjugated enynes with aryllithiums in microflow system and applications to synthesis of allenylsilanes

Yutaka Tomida; Aiichiro Nagaki; Jun-ichi Yoshida

doi:10.1021/ol901352t

Carbolithiation of conjugated enynes with aryllithiums in microflow system and applications to synthesis of allenylsilanes

Org Lett. 2009 Aug 20;11(16):3614-7. doi: 10.1021/ol901352t.

Authors

Yutaka Tomida¹, Aiichiro Nagaki, Jun-ichi Yoshida

Affiliation

¹ Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan.

PMID: 19627106
DOI: 10.1021/ol901352t

Abstract

Carbolithiation of conjugated enynes with aryllithiums generated by Br-Li exchange reaction followed by reaction of the allenyllithium compounds with chlorosilanes was carried out in a microflow system to obtain various allenylsilanes in good yields.