The distribution of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) was investigated in Mediterranean blue mussel collected at four locations in Mali Ston Bay few times a year in 2005–2007. OCPs were found in all samples and levels ranged between 0.07 and 7.58 ng g−1 dry wt. Levels of PCBs ranged between 0 (below detection limit) and 21.55 ng g−1 dry wt. For most analyzed compounds there were no significant level changes between the 3 years. Exceptions are decreased levels of β-HCH, DDD, and PCB-138 and increased levels of γ-HCH and DDT in 2007. However, mussels from this area are applicable for human diet.