Abstract
We describe a 3-year-old child who became over-sedated after receiving intranasal (IN) midazolam (0.53 mg.kg(-1)) and IN sufentanil (1 mcg.kg(-1)) for dental restorations in the dental office. Desaturation was attributed to laryngospasm, which was managed with positive pressure ventilation and oxygen. The sedation was reversed with a combination of IN flumazenil and naloxone.
MeSH terms
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Adjuvants, Anesthesia / administration & dosage
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Adjuvants, Anesthesia / antagonists & inhibitors
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Administration, Intranasal
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Anesthesia, Dental / adverse effects*
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Antidotes / administration & dosage*
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Child, Preschool
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Dental Restoration, Temporary
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Female
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Flumazenil / administration & dosage*
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Humans
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Laryngismus / etiology
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Laryngismus / therapy
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Midazolam / administration & dosage
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Midazolam / antagonists & inhibitors
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Naloxone / administration & dosage*
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Narcotic Antagonists / administration & dosage*
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Oxygen / blood
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Sufentanil / administration & dosage
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Sufentanil / antagonists & inhibitors
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Treatment Outcome
Substances
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Adjuvants, Anesthesia
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Antidotes
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Narcotic Antagonists
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Naloxone
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Flumazenil
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Sufentanil
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Midazolam
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Oxygen