Abstract
Six unreported aromatic compounds, 1-6, were isolated, along with the known compounds dehydrocurcuphenol and manoalide, from a sample of Plakortis sp., which was the main component of a Pacific sponge consortium. The new molecules were chemically characterized by spectroscopic methods. Compounds 1-4 contain a six-membered cyclic peroxide, whereas 5 and 6 display a terminal methyl ketone. The new metabolites were tested for antifungal and antibacterial properties. Compounds 1 and 4 were weakly active against S. aureus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Cyclization
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Dioxanes / chemistry
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Dioxanes / isolation & purification*
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Humans
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Ketones / chemistry
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Ketones / isolation & purification*
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Peroxides / chemistry
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Peroxides / isolation & purification*
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Porifera / chemistry*
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Terpenes / chemistry
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Terpenes / isolation & purification
Substances
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Antifungal Agents
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Dioxanes
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Ketones
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Peroxides
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Terpenes
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manoalide