Molecularly imprinted polymers--tyrosinase mimics

S A Piletsky; I A Nicholls; M I Rozhko; T A Sergeyeva; E V Piletska; A V El Skaya; I Karube

Molecularly imprinted polymers--tyrosinase mimics

Ukr Biokhim Zh (1999). 2005;77(6):63-7.

Authors

S A Piletsky¹, I A Nicholls, M I Rozhko, T A Sergeyeva, E V Piletska, A V El Skaya, I Karube

Affiliation

¹ Institute of Bioscience and Technology, Cranfield University, UK.

PMID: 19618743

Abstract

Synthetic polymers mimicking the enzyme tyrosinase have been prepared by the molecular imprinting of a complex between Cu (II) and catechol and ethyl ester of urocanic acid in an ethylene glycol dimethacrylate copolymer. Optimised polymer systems demonstrated catalysis, Michaelis-Menten kinetics and competitive inhibition similar to those of mushroom tyrosinase. The polymers benefited from superior chemical and mechanical stability in comparison with natural enzyme.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cross-Linking Reagents / chemical synthesis*
Cross-Linking Reagents / chemistry
Molecular Imprinting*
Molecular Mimicry
Molecular Structure
Monophenol Monooxygenase / chemistry*
Oxidation-Reduction
Phase Transition
Polymers / chemical synthesis*
Polymers / chemistry

Substances

Cross-Linking Reagents
Polymers
Monophenol Monooxygenase