Haemorrhagic fever of Creaman virus is a worse virus disease without specific care. It has been described in Africa and in some closed counties to Mali as Mauritania and. The purpose of this study was de determine the serological rate of Crimean Congo Virus Ig G among population living in agro pastoral region in Mali : "Office du Niger" and Baguineda. The study have been taken a period from Jun to November 1991. 228 subject have been involved from "Office du Niger" and 221 sujets from Baguineda area. We used Elisa test to detect the monoclonal antibodies Ig G againt Creaman Congo virus. No antibodies had been founded among the 228 subjects from office du Niger. But 10 subject amont the 212 subject from Baguineda area were positive that means the serological rate of Creaman Congo virus was 4,5% in this area. This study showed that the Creaman Congo virus should circulate in Mali with at lowed spead. The emphazise of the epidemiological survey must be enforced to avoid born and spraying a epidemic due to this virus in Mali and in Africa.