[Expression of microRNAs in endometrioid adenocarcinoma]

Xia Liu; Wei Xia; Yin-mei Dai; Ning-sheng Shao; Wei-yuan Zhang

[Expression of microRNAs in endometrioid adenocarcinoma]

Zhonghua Yi Xue Za Zhi. 2009 May 19;89(19):1365-7.

[Article in Chinese]

Authors

Xia Liu¹, Wei Xia, Yin-mei Dai, Ning-sheng Shao, Wei-yuan Zhang

Affiliation

¹ Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

PMID: 19615196

Abstract

Objective: To analyze miRNA expression profile of endometrioid adenocarcinoma.

Methods: Collect Endometrium was collected from cancer and park cancer tissue. And the total RNA was extracted. The microarray detection system was employed to analyze whether there was difference in microRNA expression between cancer tissue and park cancer tissue.

Results: A total of 111 differentially expressed miRNA were found, including 68 over-expression miRNA and 43 low-expression.

Conclusion: MiRNA may play important roles in tumorigenesis of endometrioid adenocarcinoma. The study of miRNA contributes to elucidate the molecular mechanism of endometrial cancer.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma, Endometrioid / metabolism*
Carcinoma, Endometrioid / pathology
Endometrial Neoplasms / metabolism*
Endometrial Neoplasms / pathology
Exosomes
Female
Gene Expression Profiling
Humans
MicroRNAs / genetics*
Oligonucleotide Array Sequence Analysis

Substances

MicroRNAs