53BP1: function and mechanisms of focal recruitment

Jennifer E FitzGerald; Muriel Grenon; Noel F Lowndes

doi:10.1042/BST0370897

53BP1: function and mechanisms of focal recruitment

Biochem Soc Trans. 2009 Aug;37(Pt 4):897-904. doi: 10.1042/BST0370897.

Authors

Jennifer E FitzGerald¹, Muriel Grenon, Noel F Lowndes

Affiliation

¹ Genome Stability Laboratory, Centre for Chromosome Biology and National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Galway, Ireland.

PMID: 19614615
DOI: 10.1042/BST0370897

Abstract

53BP1 (p53-binding protein 1) is classified as a mediator/adaptor of the DNA-damage response, and is recruited to nuclear structures termed foci following genotoxic insult. In the present paper, we review the functions of 53BP1 in DNA-damage checkpoint activation and DNA repair, and the mechanisms of its recruitment and activation following DNA damage. We focus in particular on the role of covalent histone modifications in this process.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Chromosomal Proteins, Non-Histone
DNA Damage / physiology
DNA Repair / physiology
DNA-Binding Proteins
Histones / metabolism
Humans
Intracellular Signaling Peptides and Proteins / metabolism
Intracellular Signaling Peptides and Proteins / physiology*
Models, Biological
Tumor Suppressor p53-Binding Protein 1

Substances

Chromosomal Proteins, Non-Histone
DNA-Binding Proteins
Histones
Intracellular Signaling Peptides and Proteins
TP53BP1 protein, human
Trp53bp1 protein, mouse
Tumor Suppressor p53-Binding Protein 1