HPLC-SPE-NMR identification of a novel metabolite containing the benzo[c]oxepin skeleton from the endophytic fungus Pestalotiopsis virgatula culture

Julie R Kesting; Dan Staerk; Mysore V Tejesvi; Kukkundoor R Kini; Harishchandra S Prakash; Jerzy W Jaroszewski

doi:10.1055/s-0029-1185951

HPLC-SPE-NMR identification of a novel metabolite containing the benzo[c]oxepin skeleton from the endophytic fungus Pestalotiopsis virgatula culture

Planta Med. 2009 Aug;75(10):1104-6. doi: 10.1055/s-0029-1185951. Epub 2009 Jul 16.

Authors

Julie R Kesting¹, Dan Staerk, Mysore V Tejesvi, Kukkundoor R Kini, Harishchandra S Prakash, Jerzy W Jaroszewski

Affiliation

¹ Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark.

PMID: 19609838
DOI: 10.1055/s-0029-1185951

Abstract

HPLC-SPE-NMR analysis of a crude extract of fermentation broth of cultured PESTALOTIOPSIS VIRGATULA isolate TC-320 from TERMINALIA CHEBULA Retz. (Combretaceae) disclosed the presence of a simple but unprecedented low-molecular-weight metabolite, 9-hydroxybenzo[ C]oxepin-3[1 H]-one, subsequently isolated by a targeted purification procedure.

Georg Thieme Verlag KG Stuttgart.New York.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ascomycota / chemistry*
Benzoxepins / chemistry*
Chromatography, High Pressure Liquid / methods*
Magnetic Resonance Spectroscopy / methods*

Substances

Benzoxepins