Isoplatensimycin: Synthesis and biological evaluation

Ki Po Jang; Chan Hyuk Kim; Seong Wook Na; Hiyoung Kim; Heonjoong Kang; Eun Lee

doi:10.1016/j.bmcl.2009.06.092

Isoplatensimycin: Synthesis and biological evaluation

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4601-2. doi: 10.1016/j.bmcl.2009.06.092. Epub 2009 Jun 27.

Authors

Ki Po Jang¹, Chan Hyuk Kim, Seong Wook Na, Hiyoung Kim, Heonjoong Kang, Eun Lee

Affiliation

¹ Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151-747, Republic of Korea.

PMID: 19604693
DOI: 10.1016/j.bmcl.2009.06.092

Abstract

Isoplatensimycin, a novel analog of platensimycin, was synthesized via intramolecular dipolar cycloaddition of a carbonyl ylide. Isoplatensimycin showed little activities against strains of Staphylococcus aureus, but exhibited activities against some vancomycin-resistant enteroccoci.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adamantane / analogs & derivatives*
Adamantane / chemical synthesis
Adamantane / chemistry
Adamantane / pharmacology
Aminobenzoates / chemical synthesis*
Aminobenzoates / chemistry
Aminobenzoates / pharmacology
Anilides / chemical synthesis*
Anilides / chemistry
Anilides / pharmacology
Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Enterococcus / drug effects
Methicillin-Resistant Staphylococcus aureus / drug effects
Microbial Sensitivity Tests
Vancomycin Resistance

Substances

Aminobenzoates
Anilides
Anti-Bacterial Agents
isoplatensimycin
Adamantane
platensimycin