Abstract
This work is focused on the controlled drug release behavior of hyperbranched HPMA in the presence of beta-CD. Hence, three HPMA-beta-CDs and a pure HPMA were synthesized by Michael addition polymerization. As a model drug, CLB (an anti-cancer drug) was loaded into them via a solution method for in vitro release studies. The DSC results indicate that the CLB/polymer interactions are at the molecular level. Loading CLB into these polymers results in an evident increase in their glass transition temperatures, and DeltaT(g) depends on the beta-CD content. The controlled-release experiments show that the presence of beta-CD can appropriately slow the release of CLB from HPMA-beta-CDs and adjust the ratio of CLB released in total drug loading.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Alkylating* / chemistry
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Antineoplastic Agents, Alkylating* / metabolism
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Biocompatible Materials / chemistry
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Biocompatible Materials / metabolism
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Chlorambucil* / chemistry
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Chlorambucil* / metabolism
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Delayed-Action Preparations / chemistry
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Delayed-Action Preparations / metabolism
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Drug Carriers* / chemical synthesis
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Drug Carriers* / chemistry
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Drug Carriers* / metabolism
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Drug Delivery Systems
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HeLa Cells
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Humans
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Materials Testing
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Methacrylates / chemistry
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Methacrylates / metabolism
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Molecular Structure
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Polyamines* / chemistry
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Polyamines* / metabolism
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Polymers* / chemical synthesis
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Polymers* / chemistry
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Polymers* / metabolism
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beta-Cyclodextrins* / chemistry
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beta-Cyclodextrins* / metabolism
Substances
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Antineoplastic Agents, Alkylating
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Biocompatible Materials
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Delayed-Action Preparations
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Drug Carriers
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Methacrylates
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Polyamines
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Polymers
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beta-Cyclodextrins
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Chlorambucil
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betadex
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hydroxypropyl methacrylate