Antiviral properties of glycyrrhizic acid and its semisynthetic derivatives

Mini Rev Med Chem. 2009 Jul;9(8):996-1001. doi: 10.2174/138955709788681636.

Abstract

Some natural triterpenes exert a definite antiviral activity on several human viruses. New synthetic derivatives of glycyrrhizic acid (GL) are even more active than the parental molecule. GL can alter the expression of viral genes involved in cell transformation, thus opening a new window for speculating on viral cancerogenesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Antiviral Agents / chemical synthesis
  • Antiviral Agents / chemistry*
  • Antiviral Agents / pharmacology*
  • Gene Expression Regulation, Viral / drug effects
  • Glycyrrhizic Acid / analogs & derivatives
  • Glycyrrhizic Acid / chemical synthesis
  • Glycyrrhizic Acid / chemistry*
  • Glycyrrhizic Acid / pharmacology*
  • Humans
  • Viruses / drug effects*
  • Viruses / genetics
  • Viruses / growth & development

Substances

  • Antiviral Agents
  • Glycyrrhizic Acid