A positive spin on the centromere

Cell. 2009 Jul 10;138(1):22-4. doi: 10.1016/j.cell.2009.06.037.

Abstract

The properties of centromeric nucleosomes have been the subject of considerable debate and controversy. Furuyama and Henikoff (2009) now provide surprising evidence that centromeric nucleosomes wrap DNA in an orientation that is opposite to that of canonical nucleosomes.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Centromere / chemistry*
  • DNA / chemistry*
  • DNA / metabolism
  • Drosophila / chemistry
  • Drosophila Proteins / metabolism
  • Histones / metabolism
  • Models, Molecular
  • Nucleic Acid Conformation
  • Nucleosomes / chemistry*

Substances

  • Drosophila Proteins
  • Histones
  • Nucleosomes
  • DNA