Objective: To review the role of hypoxia inducible factor 1alpha (HIF-1alpha) in hypoxic-ischemic injury and its repair, and to analyze the possible mechanisms.
Methods: Recent literature on HIF-1alpha and its role in hypoxic-ischemic injury was reviewed and analyzed.
Results: HIF-1alpha was involved in the hypoxic-ischemic injury of various organs or tissues and their repair processes.
Conclusion: HIF-1alpha has a potential to treat common clinical hypoxic-ischemic injuries and has a promising future for application.