This qualitative study was part of the pre-implementation formative evaluation of SelectHealth's Continuity of Care Record (CCR), an electronic health information network (EHI) for HIV/AIDS care in New York City (NYC). The purpose of the study was to explore case managers' perceptions of the barriers to adoption of the CCR. Focus group methodology was used to gather perceptions from 26 participants who provided direct case management services for persons living with HIV/AIDS (PLWHA) in NYC. Question development was guided by models of technology acceptance. Data about the barriers to implementation of the system were classified into four main themes: client capacity for system adoption, potential breech of confidentiality, information quality concerns, and training needs. The four identified themes can serve as focal points for developers seeking to create EHI networks for the provision of HIV care.