User-friendly stereoselective one-pot access to 1,4-diazepane derivatives by a cyclodehydrative three-component reaction with 1,3-dicarbonyls

Org Biomol Chem. 2009 May 7;7(9):1911-20. doi: 10.1039/b821343g. Epub 2009 Mar 20.

Abstract

A multicomponent reaction of 1,3-dicarbonyls with 1,2-diamines and aromatic aldehydes is described for the direct stereoselective synthesis of 1,4-diazepane derivatives. Various reaction conditions were tested, including an efficient, user-friendly solvent- and catalyst-free procedure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azepines*
  • Carbon Compounds, Inorganic / chemistry*
  • Catalysis
  • Cyclization
  • Models, Molecular
  • Molecular Structure
  • Solvents
  • Stereoisomerism
  • Water / chemistry*

Substances

  • Azepines
  • Carbon Compounds, Inorganic
  • Solvents
  • Water