Abstract
Combination therapy has become the standard for the management of acne, particularly for moderate-to-severe cases. Among these combinations, those regimens containing benzoyl peroxide (BPO), clindamycin and a retinoid have been used frequently as they address most aspects of acne pathogenesis. This study compares the efficacy and safety of two common topical treatment regimens in the treatment of a moderate to severe facial acne vulgaris: fixed-combination gel containing BPO 5% and clindamycin 1% (BPO/C) plus tretinoin microsphere gel 0.04% (RAM) versus a regimen of a fixed-combination gel containing clindamycin phosphate 1.2% and tretinoin 0.025% (CPT) plus a once-daily BPO 5% wash. While both regimens were safe and effective, regimen BPO/C+RAM yielded a more rapid onset of effect versus regimen CPT+BPO against both non-inflammatory and inflammatory lesions. Both treatment regimens were well-tolerated.
Publication types
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Comparative Study
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Multicenter Study
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Randomized Controlled Trial
MeSH terms
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Acne Vulgaris / drug therapy*
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Acne Vulgaris / microbiology
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Administration, Cutaneous
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Adolescent
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Adult
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Anti-Bacterial Agents / adverse effects
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Anti-Bacterial Agents / therapeutic use*
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Benzoyl Peroxide / adverse effects
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Benzoyl Peroxide / therapeutic use
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Child
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Clindamycin / adverse effects
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Clindamycin / therapeutic use
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Dermatologic Agents / adverse effects
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Dermatologic Agents / therapeutic use*
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Drug Combinations
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Drug Therapy, Combination
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Female
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Gels
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Humans
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Keratolytic Agents / adverse effects
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Keratolytic Agents / therapeutic use
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Male
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Propionibacterium acnes / drug effects
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Prospective Studies
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Severity of Illness Index
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Single-Blind Method
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Treatment Outcome
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Tretinoin / adverse effects
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Tretinoin / therapeutic use
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Young Adult
Substances
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Anti-Bacterial Agents
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Dermatologic Agents
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Drug Combinations
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Gels
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Keratolytic Agents
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Clindamycin
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Tretinoin
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Benzoyl Peroxide