Abalones, belonging to one of the largest marine gastropod mollusks, are economically important seafood in aquaculture worldwide. In recent years, bacterial epidemic infection has been reported in China and other countries, and mass mortality in abalones causes significant economic losses. Immune-related genes and proteins of abalones are seldom reported. However, these functional molecules may play a key role in resisting diseases and maintaining healthy status and are pivotal for studying immunological mechanisms. Here we summarized the advanced research and progresses in abalone immune-related genes and proteins with the purpose of facilitating future study of these target molecules involved in immunological mechanisms.