Abstract
A useful Michael addition reaction using nitroalkanes as the nucleophile and 4-oxo-enoates as the Michael acceptor has been disclosed, and the reaction allows expedient access to functionalized chiral gamma-keto esters in high yields and excellent enantioselectivities (up to 98% ee), with a low catalyst loading.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkanes / chemistry*
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Butyrates / chemistry*
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Catalysis
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Crystallography, X-Ray
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Models, Molecular
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Nitro Compounds / chemistry*
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Organic Chemicals / chemistry*
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Stereoisomerism
Substances
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6-(nitrooxy)hexyl-(2z)-4-(acetyloxy)-3-(4-(methylsulfonyl)phenyl)-2-phenylbut-2-enoate
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Alkanes
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Butyrates
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Nitro Compounds
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Organic Chemicals