Abstract
In general, Indians have low HDL cholesterol levels. Fenofibrate, a drug widely used in the treatment of hypertriglyceridemia, usually also increases HDL cholesterol. There have been a few reports in the literature of a paradoxical decrease in serum HDL-cholesterol in patients treated with fenofibrate, either alone or in combination with a statin. We report three cases of paradoxical decrease in serum HDL-cholesterol in type 2 diabetic patients treated with a statin-fenofibrate combination.
MeSH terms
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Atorvastatin
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Cholesterol, HDL / blood*
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Diabetes Mellitus, Type 2 / blood*
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Diabetes Mellitus, Type 2 / complications
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Diabetes Mellitus, Type 2 / therapy
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Drug Therapy, Combination
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Dyslipidemias / blood
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Dyslipidemias / complications
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Dyslipidemias / drug therapy*
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Fenofibrate / administration & dosage*
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Heptanoic Acids / administration & dosage*
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Humans
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Hypolipidemic Agents / administration & dosage*
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Male
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Middle Aged
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Pyrroles / administration & dosage*
Substances
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Cholesterol, HDL
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Heptanoic Acids
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Hypolipidemic Agents
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Pyrroles
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Atorvastatin
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Fenofibrate