Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) is serious clinical urgent problems worldwide. In the present study, the antibacterial activity of Hylomecon hylomeconoides was investigated. The EtOH extract and its fraction (n-hexane, CH(2)Cl(2), EtOAc, and H(2)O) were investigated against MRSA. The most active extract (CH(2)Cl(2)) led to the isolation of 6-methoxydihydrosanguinarine (6-MS), 6-acetonylhydrosanguinarine, and dihydrosanguinarine. These compounds were very active against MRSA strains with minimum inhibitory concentrations (MICs) ranging from 1.95 to 250 microg/ml. Our study did however focus on 6-MS as it appeared to be the most active with MICs in the range of 1.9 to 3.9 microg/ml. These results encourage us to think that 6-MS can be used as a natural antibacterial agent.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use
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Bacterial Proteins / genetics
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Benzophenanthridines / chemistry
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Benzophenanthridines / pharmacology*
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Benzophenanthridines / therapeutic use
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Isoquinolines / chemistry
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Isoquinolines / pharmacology*
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Isoquinolines / therapeutic use
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Microbial Sensitivity Tests
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Papaveraceae / chemistry*
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Penicillin-Binding Proteins
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Staphylococcal Infections / drug therapy
Substances
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6-methoxydihydrosanguinarine
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Anti-Bacterial Agents
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Bacterial Proteins
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Benzophenanthridines
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Isoquinolines
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Penicillin-Binding Proteins
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Plant Extracts
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mecA protein, Staphylococcus aureus