Advances in dissecting mosquito innate immune responses to arbovirus infection

J Gen Virol. 2009 Sep;90(Pt 9):2061-72. doi: 10.1099/vir.0.013201-0. Epub 2009 Jul 1.

Abstract

Arthropod-borne viruses - arboviruses - are a significant threat to public health. Whilst there is considerable knowledge about arbovirus interactions with vertebrate immunity, relatively little is known about how vectors such as mosquitoes control arbovirus infections. In this review, we discuss novel findings in the field of mosquito antiviral responses to arboviruses, in particular RNA interference, the up-and-coming field of general immune-signalling pathways, and cell death/apoptosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Arbovirus Infections / transmission
  • Arbovirus Infections / virology*
  • Arboviruses / immunology*
  • Culicidae / genetics
  • Culicidae / immunology*
  • Culicidae / virology*
  • Humans
  • Immunity, Innate*
  • Insect Vectors / genetics
  • Insect Vectors / immunology*
  • Insect Vectors / virology