Relationships between mandibular cortical bone measures and biochemical markers of bone turnover in elderly Japanese men and women

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Nov;108(5):777-83. doi: 10.1016/j.tripleo.2009.03.043. Epub 2009 Jul 1.

Abstract

Objective: The aim was to clarify the association between dental panoramic radiography measures of mandibular inferior cortical shape and biochemical markers of bone turnover in elderly men and women.

Study design: Subjects were 80-year-old men (n = 85) and women (n = 153). Mandibular cortical shape and width were evaluated on dental panoramic radiographs. Bone formation and resorption, respectively, were estimated by serum levels of carboxy-terminal propeptide of type I collagen (PICP) and serum type I collagen carboxy-terminal telopeptide (ICTP).

Results: Eroded cortices of the mandible were significantly associated with increased serum PICP levels (P = .005) in women. Lower mandibular cortical width quartiles were also significantly associated with increased serum PICP levels in men (P = .020) and women (P = .006).

Conclusions: Mandibular inferior cortical measures detected on dental panoramic radiographs may be associated with bone formation rates and be useful in predicting osteoporosis in elderly Japanese men and women.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biomarkers / blood
  • Bone Remodeling*
  • Collagen Type I
  • Female
  • Humans
  • Japan
  • Male
  • Mandible / diagnostic imaging*
  • Osteoporosis / blood*
  • Peptide Fragments / blood*
  • Peptides
  • Predictive Value of Tests
  • Procollagen / blood*
  • Radiography, Panoramic
  • Sex Factors

Substances

  • Biomarkers
  • Collagen Type I
  • Peptide Fragments
  • Peptides
  • Procollagen
  • collagen type I trimeric cross-linked peptide
  • procollagen type I carboxy terminal peptide