Abstract
Bicyclic iminosugar derivatives with an ether bridge bearing different substituents on C-2 and the nitrogen atom have been synthesized from a C-glycoside bearing an isopropylidene acetal. The activities of these compounds were investigated against several glycosidase enzymes and showed moderate inhibition and activation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bridged Bicyclo Compounds, Heterocyclic / chemistry*
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Cattle
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Enzyme Activation / drug effects
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Ethers / chemistry*
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Glycoside Hydrolases / antagonists & inhibitors
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Imino Sugars / chemical synthesis*
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Imino Sugars / chemistry
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Imino Sugars / pharmacology*
Substances
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Bridged Bicyclo Compounds, Heterocyclic
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Enzyme Inhibitors
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Ethers
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Imino Sugars
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Glycoside Hydrolases