"Clickable" elastins: elastin-like polypeptides functionalized with azide or alkyne groups

Rosalie L M Teeuwen; Sander S van Berkel; Tim H H van Dulmen; Sanne Schoffelen; Silvie A Meeuwissen; Han Zuilhof; Frits A de Wolf; Jan C M van Hest

doi:10.1039/b903903a

"Clickable" elastins: elastin-like polypeptides functionalized with azide or alkyne groups

Chem Commun (Camb). 2009 Jul 21:(27):4022-4. doi: 10.1039/b903903a. Epub 2009 Apr 21.

Authors

Rosalie L M Teeuwen¹, Sander S van Berkel, Tim H H van Dulmen, Sanne Schoffelen, Silvie A Meeuwissen, Han Zuilhof, Frits A de Wolf, Jan C M van Hest

Affiliation

¹ Radboud University Nijmegen, Institute for Molecules and Materials, Department of Organic Chemistry, P.O. Box 9010, 6500 GL Nijmegen, The Netherlands.

PMID: 19568620
DOI: 10.1039/b903903a

Abstract

Elastin-like polypeptides (ELPs) functionalized with azide or alkyne groups were produced biosynthetically and coupled via the Cu-catalyzed azide-alkyne cycloaddition to a variety of (bio)molecules.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkynes / chemistry*
Azides / chemistry*
Catalysis
Copper / chemistry
Elastin / chemistry*
Elastin / genetics
Electrophoresis, Polyacrylamide Gel
Fluorescent Dyes
Oligopeptides / chemistry*
Oligopeptides / genetics
Protein Engineering

Substances

Alkynes
Azides
Fluorescent Dyes
Oligopeptides
Copper
Elastin