Heterochromatin protein 1 is extensively decorated with histone code-like post-translational modifications

Mol Cell Proteomics. 2009 Nov;8(11):2432-42. doi: 10.1074/mcp.M900160-MCP200. Epub 2009 Jun 30.

Abstract

Heterochromatin protein 1 (HP1) family members (alpha, beta, and gamma) bind histone H3 methylated at Lys-9, leading to gene silencing and heterochromatin formation. Several previous reports have suggested that HP1s are post-translationally modified, yet sites of modification have not yet been exhaustively determined. Here we perform the first comprehensive proteomic analysis of all HP1 isoforms using tandem mass spectrometry. Our data reveal that all HP1 isoforms are highly modified in a manner analogous to histones including phosphorylation, acetylation, methylation, and formylation, including several sites having multiple different types of modifications. Additionally, many of these modifications are found in both the chromo- and chromoshadow domains, suggesting that they may have an important role in modulating HP1 interactions or functions. These studies are the first to systematically map the abundant sites of covalent modifications on HP1 isoforms and provide the foundation for future investigations to test whether these modifications are essential in heterochromatin maintenance or other nuclear processes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Nucleus / metabolism
  • Chromatography, Liquid / methods
  • Chromobox Protein Homolog 5
  • Chromosomal Proteins, Non-Histone / chemistry*
  • Chromosomal Proteins, Non-Histone / metabolism
  • Drosophila
  • Histones / chemistry*
  • Humans
  • Mass Spectrometry / methods
  • Molecular Sequence Data
  • Peptides / chemistry
  • Protein Isoforms
  • Protein Processing, Post-Translational*
  • Proteomics / methods
  • Tandem Mass Spectrometry / methods

Substances

  • Chromosomal Proteins, Non-Histone
  • Histones
  • Peptides
  • Protein Isoforms
  • Chromobox Protein Homolog 5