Recognition of traditional Chinese medicine for the structures of channels and collaterals is possibly related with the tactics of human early general medical study, characterized by "inner", sub-micro, entirety, etc. The mechanisms are possibly involved in direct communication pathway of the cell junction (specially keeping the relevant cellular direct communication relation in individual development), the extra-cellular matrix stress network system and its biophysical message transmission--force--meridian signs transformation--inter-cellular massage integration, and "generalization" of the structures and activities of channels and collaterals in acupuncture serum phenomenon, etc. Thus, the hypothesis of multi-factors about channel structures-mechanisms is proposed.