Vancomycin and daptomycin pharmacodynamics differ against a site-directed Staphylococcus epidermidis mutant displaying the small-colony-variant phenotype

Antimicrob Agents Chemother. 2009 Sep;53(9):3992-5. doi: 10.1128/AAC.01597-08. Epub 2009 Jun 29.

Abstract

Catheter-related bloodstream infections due to slow-growing Staphylococcus epidermidis small-colony variants (SCVs) are extremely difficult to treat. Daptomycin and vancomycin pharmacodynamics were evaluated against a site-directed hemB mutant of S. epidermidis displaying the SCV phenotype and compared to that of the parental strain. The maximal killing effect decreased by 7.7-fold for vancomycin and 1.5-fold for daptomycin against the SCV mutant and were well characterized by a Hill-type mathematical model (R2 > 0.97).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Daptomycin / pharmacology*
  • Models, Theoretical
  • Mutagenesis, Site-Directed
  • Mutation
  • Phenotype
  • Staphylococcus epidermidis / drug effects*
  • Staphylococcus epidermidis / genetics*
  • Vancomycin / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Vancomycin
  • Daptomycin