Bis-anthracenyl isoxazolyl amides have enhanced anticancer activity

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4067-9. doi: 10.1016/j.bmcl.2009.06.019. Epub 2009 Jun 13.

Abstract

Dimeric analogs of Anthracenyl Isoxazole Amides (AIMs) (the designation AIM is in honor of the memory of Professor Albert I. Meyers) were prepared and dimer 6 exhibited the highest efficacy to date for this class of anti-tumor compounds against the human glioma Central Nervous System cell line SNB-19.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amides / chemical synthesis
  • Amides / pharmacology*
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Brain Neoplasms / drug therapy*
  • Cell Line, Tumor
  • Chemistry, Pharmaceutical / methods*
  • DNA / chemistry
  • Dimerization
  • Drug Screening Assays, Antitumor
  • Glioma / drug therapy*
  • Humans
  • Hydrogen-Ion Concentration
  • Models, Chemical
  • Molecular Conformation

Substances

  • Amides
  • Antineoplastic Agents
  • DNA