Sediment quality guidelines (SQGs) are an important tool for the assessment of contamination in marine and estuarine sediments. Although such guidelines are not definitive indicators of toxicity, they can have a high predictive ability and are a vital tool for identifying areas with potentially adverse biological effects. In the present study, 15 sets of common SQGs have been compared, including values for Australia/New Zealand, Canada, Hong Kong, Norway, the Netherlands, the USA and regions within the USA (Puget Sound/Washington, New York and Florida). The majority of these SQGs are based on the weight-of-evidence approach. In particular, the sub-group of TEL/PEL-based values have a very high degree of comparability; values not belonging to this uniform group show substantial variations.