Intraoperative MRI (iMRI) can be applied in several surgical settings. The incorporation of MRI technology into the operating room requires special considerations. The size and design of the operating room, including the equipment introduced into this setting, must be MR safe and allow adequate anesthesia monitoring and care. There are general restrictions and perils that may present in an operating room setting because of the MRI technology involving the monitoring equipment, anesthesia machine, and infusion devices. Incorporating the MRI technology into the operating room presents a new challenge in a transdisciplinary environment. The use of the iMRI technology has provided revolutionary tools for the new generation of medical practice.