Epstein-Barr virus antibody level and gastric cancer risk in Korea: a nested case-control study

Y Kim; A Shin; J Gwack; K-P Ko; C-S Kim; S K Park; Y-C Hong; D Kang; K-Y Yoo

doi:10.1038/sj.bjc.6605146

Epstein-Barr virus antibody level and gastric cancer risk in Korea: a nested case-control study

Br J Cancer. 2009 Aug 4;101(3):526-9. doi: 10.1038/sj.bjc.6605146. Epub 2009 Jun 23.

Authors

Y Kim¹, A Shin, J Gwack, K-P Ko, C-S Kim, S K Park, Y-C Hong, D Kang, K-Y Yoo

Affiliation

¹ Cancer Early Detection Branch, National Cancer Control Research Institute, National Cancer Center, 111 Jungbalsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-769, Korea.

Abstract

Background: Few cohort studies have investigated Epstein-Barr virus (EBV) infection before the occurrence of gastric cancer.

Methods: Among 14,440 cohort participants, 100 incident gastric cancer cases were individually matched to two controls. Epstein-Barr virus antibodies IgG and IgA against viral capsid antigen (VCA), EBV nuclear antigen (EBNA) antibody IgG, and early antigen (EA) antibody IgG were measured using enzyme immunoassays (EIAs).

Results: The highest titres of VCA IgG (odds ratio (OR): 1.37, 95% confidence interval (CI): 0.62-3.06) or EBNA IgG (OR: 0.87, 95% CI: 0.51-1.46) were not associated with gastric cancer risk.

Conclusion: Higher levels of VCA IgG or EBNA IgG were not associated with increased risk of gastric adenocarcinoma in Koreans.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Antibodies, Viral / blood*
Capsid Proteins / immunology
Case-Control Studies
Epstein-Barr Virus Nuclear Antigens / immunology
Female
Helicobacter Infections / complications
Helicobacter pylori
Herpesvirus 4, Human / isolation & purification*
Humans
Immunoglobulin G / blood
Male
Middle Aged
Stomach Neoplasms / etiology
Stomach Neoplasms / virology*

Substances

Antibodies, Viral
Capsid Proteins
Epstein-Barr Virus Nuclear Antigens
Immunoglobulin G