Interaction of indoleamine-2,3-dioxyagnase and CD4+CD25+ regulatory T cells in tumor immune escape

Ai Zheng. 2009 Feb;28(2):184-7. Epub 2009 Feb 12.

Abstract

There are numerous factors involved in the tumor evasion from immune surveillance. Recently, considerable attention has been given to indoleamine 2,3-dioxygenase (IDO) and CD4(+)CD25(+) regulatory T cells (Tregs). The interaction between the two may play a crucial role in tumor immune escape. This article reviews the correlation between IDO and Tregs in immune escape of tumors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Indoleamine-Pyrrole 2,3,-Dioxygenase / metabolism*
  • Interleukin-2 Receptor alpha Subunit / immunology
  • Models, Biological
  • Protein Binding
  • Protein Serine-Threonine Kinases / metabolism
  • Signal Transduction / immunology
  • T-Lymphocytes, Regulatory / immunology*
  • T-Lymphocytes, Regulatory / metabolism
  • Tumor Escape / immunology*

Substances

  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Interleukin-2 Receptor alpha Subunit
  • EIF2AK4 protein, human
  • Protein Serine-Threonine Kinases