Clarithromycin susceptibility testing of Mycobacterium avium complex using 2,3-diphenyl-5-thienyl-(2)-tetrazolium chloride microplate assay with Middlebrook 7H9 broth

J Korean Med Sci. 2009 Jun;24(3):511-2. doi: 10.3346/jkms.2009.24.3.511. Epub 2009 Jun 15.

Abstract

A series of 119 Mycobacterium avium complex isolates were subjected to clarithromycin susceptibility testing using microplates containing 2,3-diphenyl-5-thienyl-(2)-tetrazolium chloride (STC). Among 119 isolates, 114 (95.8%) were susceptible to clarithromycin and 5 were resistant according to the new and the standard method. STC counts the low cost and reduces the number of procedures needed for susceptibility testing.

Keywords: Clarithromycin; Microtiter Method; Mycobacterium Avium Complex; Susceptibility Testing; Tetrazolium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Clarithromycin / pharmacology*
  • Culture Media
  • Humans
  • Microbial Sensitivity Tests / methods*
  • Mycobacterium avium Complex / drug effects*
  • Mycobacterium avium Complex / isolation & purification
  • Tetrazolium Salts / chemistry*

Substances

  • 2,3-diphenyl-5-thienyl-(2)-tetrazolium
  • Culture Media
  • Tetrazolium Salts
  • Clarithromycin