Abstract
A formal total synthesis of the antitubercular natural product was accomplished. This work was undertaken to address certain stereochemical problems in our initial synthesis. By using an ester group as a surrogate for a methyl group, we were able to intercept a key intermediate in our first synthesis with better selectivity and greater convergence than had previously been the case.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Antitubercular Agents / chemical synthesis*
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Antitubercular Agents / chemistry
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Biological Factors / chemical synthesis*
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Biological Factors / chemistry
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Cyclization
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Diterpenes / chemical synthesis*
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Diterpenes / chemistry
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Molecular Structure
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Oxazoles / chemical synthesis*
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Oxazoles / chemistry
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Stereoisomerism
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Thiazines / chemical synthesis*
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Thiazines / chemistry
Substances
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Antitubercular Agents
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Biological Factors
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Diterpenes
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Oxazoles
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Thiazines
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pseudopteroxazole