Abstract
CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, Helicobacter pylori (H pylori). The role of CD74 as a receptor is important because after binding of migration inhibitory factor or H pylori, NF-kappaB and Erk1/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antigen Presentation / immunology*
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Antigens, Differentiation, B-Lymphocyte / immunology*
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Gastrointestinal Neoplasms / immunology*
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Helicobacter Infections / immunology
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Helicobacter pylori / immunology
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Histocompatibility Antigens Class II / immunology*
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Humans
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Inflammation / immunology*
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Interleukin-8 / immunology
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Macrophage Migration-Inhibitory Factors / immunology
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Protein Isoforms / immunology
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Signal Transduction / immunology
Substances
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Antigens, Differentiation, B-Lymphocyte
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Histocompatibility Antigens Class II
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Interleukin-8
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Macrophage Migration-Inhibitory Factors
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Protein Isoforms
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invariant chain