Abstract
Progressive renal fibrosis is common to all chronic kidney diseases (CKD). Suthanthiran and colleagues identified a positive association between transforming growth factor-beta1 and several risk factors for CKD progression in African Americans but not in whites. This study offers a possible explanation for the higher prevalence of end-stage renal disease in African Americans and highlights the need for a better therapeutic strategy for this population.
Publication types
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Comment
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Biomarkers / blood
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Black or African American / statistics & numerical data*
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Disease Progression
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Humans
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Kidney Failure, Chronic / blood*
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Kidney Failure, Chronic / ethnology*
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Models, Biological
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Population Groups / statistics & numerical data*
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Prevalence
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Risk Factors
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Transforming Growth Factor beta1 / blood*
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United States / epidemiology
Substances
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Biomarkers
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TGFB1 protein, human
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Transforming Growth Factor beta1