Abstract
Polyanion-based microbicides have been developed to prevent the sexual transmission of human immunodeficiency virus (HIV). Recent data suggest that polyanions have the capacity to enhance HIV type 1 (HIV-1) replication at threshold antiviral concentrations. Evaluation of the microbicide candidates SPL7013 and PRO 2000 revealed no specific enhancement of two CCR5 HIV-1 strains in human peripheral blood mononuclear cells compared to enfuvirtide (Fuzeon). The enhancement effect is likely to be a function of the assay conditions and is not an intrinsic property of these polyanions.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Anti-HIV Agents / pharmacology*
-
Cells, Cultured
-
Dendrimers
-
Enfuvirtide
-
HIV Envelope Protein gp41 / pharmacology
-
HIV-1 / drug effects*
-
HIV-1 / genetics
-
HIV-1 / physiology*
-
Humans
-
Naphthalenesulfonates / pharmacology
-
Peptide Fragments / pharmacology
-
Polyelectrolytes
-
Polylysine / pharmacology
-
Polymers / chemistry*
-
Polymers / pharmacology*
-
Virus Replication / drug effects*
Substances
-
Anti-HIV Agents
-
Dendrimers
-
HIV Envelope Protein gp41
-
Naphthalenesulfonates
-
PRO 2000
-
Peptide Fragments
-
Polyelectrolytes
-
Polymers
-
polyanions
-
Enfuvirtide
-
Polylysine
-
astodrimer