Abstract
7-Ketocholesterol (7-Kchol, oxidized cholesterol) is an important mediator of cell death in atherosclerosis mediated by up-regulated Nox 4 gene expression. In the current study using the human colon cancer HT-29 cell line, we have demonstrated that 7-Kchol promotes endoplasmic reticulum (ER) stress via gene up-regulation of ER chaperone and membrane kinases.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line, Tumor
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Colonic Neoplasms
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DNA Primers
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Endoplasmic Reticulum / drug effects
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Endoplasmic Reticulum / physiology*
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HT29 Cells / drug effects
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HT29 Cells / physiology*
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Humans
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Ketocholesterols / pharmacology*
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Reverse Transcriptase Polymerase Chain Reaction
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Signal Transduction / drug effects
Substances
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DNA Primers
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Ketocholesterols
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7-ketocholesterol