Abstract
We analyzed the structure of the expression site encoding the immunoprotective protein MSP2/P44 from multiple Anaplasma phagocytophilum strains in the United States. The sequence of p44ESup1 had diverged in Ap-variant 1 strains infecting ruminants. In contrast, no differences were detected between A. phagocytophilum strains infecting humans and domestic dogs.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Amino Acid Sequence
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Anaplasma phagocytophilum / classification*
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Anaplasma phagocytophilum / genetics*
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Animals
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Bacterial Outer Membrane Proteins / chemistry
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Bacterial Outer Membrane Proteins / genetics
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Bacterial Outer Membrane Proteins / metabolism
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Dog Diseases / epidemiology
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Dog Diseases / microbiology
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Dogs
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Ehrlichiosis / epidemiology*
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Ehrlichiosis / microbiology
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Gene Expression Regulation, Bacterial
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Genetic Variation*
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Humans
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Molecular Sequence Data
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Polymerase Chain Reaction / methods
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Sequence Analysis, DNA
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United States / epidemiology
Substances
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Bacterial Outer Membrane Proteins
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msp2 protein, Anaplasma phagocytophilum
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p44 protein, Anaplasma phagocytophila
Associated data
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GENBANK/FJ467331
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GENBANK/FJ467332
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GENBANK/FJ467333
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GENBANK/FJ467334
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GENBANK/FJ467335
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GENBANK/FJ467336
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GENBANK/FJ467337
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GENBANK/FJ467338
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GENBANK/FJ467339
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GENBANK/FJ467340