Diversity of Anaplasma phagocytophilum strains, USA

Emerg Infect Dis. 2009 Jun;15(6):928-31. doi: 10.3201/eid1506.081610.

Abstract

We analyzed the structure of the expression site encoding the immunoprotective protein MSP2/P44 from multiple Anaplasma phagocytophilum strains in the United States. The sequence of p44ESup1 had diverged in Ap-variant 1 strains infecting ruminants. In contrast, no differences were detected between A. phagocytophilum strains infecting humans and domestic dogs.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amino Acid Sequence
  • Anaplasma phagocytophilum / classification*
  • Anaplasma phagocytophilum / genetics*
  • Animals
  • Bacterial Outer Membrane Proteins / chemistry
  • Bacterial Outer Membrane Proteins / genetics
  • Bacterial Outer Membrane Proteins / metabolism
  • Dog Diseases / epidemiology
  • Dog Diseases / microbiology
  • Dogs
  • Ehrlichiosis / epidemiology*
  • Ehrlichiosis / microbiology
  • Gene Expression Regulation, Bacterial
  • Genetic Variation*
  • Humans
  • Molecular Sequence Data
  • Polymerase Chain Reaction / methods
  • Sequence Analysis, DNA
  • United States / epidemiology

Substances

  • Bacterial Outer Membrane Proteins
  • msp2 protein, Anaplasma phagocytophilum
  • p44 protein, Anaplasma phagocytophila

Associated data

  • GENBANK/FJ467331
  • GENBANK/FJ467332
  • GENBANK/FJ467333
  • GENBANK/FJ467334
  • GENBANK/FJ467335
  • GENBANK/FJ467336
  • GENBANK/FJ467337
  • GENBANK/FJ467338
  • GENBANK/FJ467339
  • GENBANK/FJ467340