To be excluded or to bind, that is the question: Arginine effects on proteins

Curr Pharm Biotechnol. 2009 Jun;10(4):415-20. doi: 10.2174/138920109788488824.

Abstract

In spite of its wide application to protein refolding, purification, and storage, we have not yet addressed a general solution to the mechanism of the effects of arginine hydrochloride on proteins. To elucidate the mechanism of the effects on proteins, several attempts have been reported. In this review, we would review the attempts from thermodynamic and kinetic viewpoints.

Publication types

  • Review

MeSH terms

  • Arginine / chemistry*
  • Binding Sites
  • Biopharmaceutics / methods*
  • Chemical Fractionation / methods
  • Multiprotein Complexes / chemistry*
  • Multiprotein Complexes / isolation & purification*
  • Protein Binding
  • Proteins / chemistry*
  • Proteins / isolation & purification*
  • Technology, Pharmaceutical / methods*

Substances

  • Multiprotein Complexes
  • Proteins
  • Arginine