Studying the photoprotective activity of a new class of heteroaromatic antioxidants

Bull Exp Biol Med. 2009 Feb;147(2):193-5. doi: 10.1007/s10517-009-0472-8.

Abstract

Photoprotective activity of heteroaromatic compounds (derivatives of 3-hydroxypyridine, amino-6-hydroxybenzothiazole, and 5-hydroxybenzimidazole) was studied in the system of UV-induced cardiolipin peroxidation. Although all three compounds had the antioxidant effect during free radical oxidation of luminol, only derivatives of amino-6-hydroxybenzothiazole and 5-hydroxybenzimidazole inhibited the process of UV-induced lipid peroxidation. The 3-hydroxypyridine derivative did not inhibit UV-induced cardiolipin peroxidation, which was probably related to degradation of this compound under the influence of UV light and formation of degradation products that cannot inhibit free radical processes.

MeSH terms

  • Antioxidants / chemistry
  • Antioxidants / pharmacology*
  • Benzimidazoles / chemistry
  • Cardiolipins / chemistry
  • Free Radicals / chemistry
  • Lipid Peroxidation / drug effects*
  • Lipid Peroxidation / radiation effects*
  • Molecular Structure
  • Oxidation-Reduction / drug effects
  • Oxidation-Reduction / radiation effects
  • Pyridines / chemistry
  • Thiazoles / chemistry
  • Ultraviolet Rays

Substances

  • Antioxidants
  • Benzimidazoles
  • Cardiolipins
  • Free Radicals
  • Pyridines
  • Thiazoles
  • 6-hydroxybenzothiazole
  • 5-hydroxybenzimidazole
  • 3-hydroxypyridine