Effect of lysosomotropic form of amphotericin B on functional state of phagocytes in experimental candidiasis

V V Kurilin; M A Saperova; E A Efanov; D D Tsyrendorzhiev; V A Shkurupiy

doi:10.1007/s10517-009-0397-2

Effect of lysosomotropic form of amphotericin B on functional state of phagocytes in experimental candidiasis

Bull Exp Biol Med. 2008 Dec;146(6):698-700. doi: 10.1007/s10517-009-0397-2.

[Article in English, Russian]

Authors

V V Kurilin¹, M A Saperova, E A Efanov, D D Tsyrendorzhiev, V A Shkurupiy

Affiliation

¹ Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Russia. medinfo@ngs.ru

PMID: 19513358
DOI: 10.1007/s10517-009-0397-2

Abstract

Effect of antifungal preparation amphotericin B and its lysosomotropic composition with dialdehyde-dextran on functional state of phagocytizing cells in the dynamics of granulomatous inflammation induced by C. albicans was studied on CBA mice. A stimulating effect of amphotericin B on the production of reactive oxygen species by peritoneal and bone marrow phagocytes was observed, while lysosomotropic form of the antibiotic did not stimulate generation of oxygen radicals.

MeSH terms

Amphotericin B / pharmacology*
Amphotericin B / therapeutic use*
Animals
Antifungal Agents / pharmacology*
Antifungal Agents / therapeutic use*
Candidiasis / drug therapy*
Disease Models, Animal
Mice
Phagocytes / drug effects*
Phagocytes / metabolism
Reactive Oxygen Species / metabolism

Substances

Antifungal Agents
Reactive Oxygen Species
Amphotericin B