Linear IgA bullous dermatosis induced by interferon-alpha 2a

Clin Exp Dermatol. 2009 Jul;34(5):e123-4. doi: 10.1111/j.1365-2230.2008.03160.x.

Abstract

Linear Ig A bullous dermatosis (LABD) is an acquired autoimmune subepidermal blistering disorder with linear deposits of IgA along the basement membrane zone. Its cause is unclear, although it appears to have an immune-mediated basis. Idiopathic, systemic disorder-related, and rarely drug-induced forms of LABD have been described. We describe a case of LABD associated with interferon-alpha 2A used for the treatment of Kaposi's sarcoma.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Drug Eruptions / etiology*
  • Female
  • Humans
  • Immunoglobulin A / analysis*
  • Interferon alpha-2
  • Interferon-alpha / adverse effects*
  • Interferon-alpha / therapeutic use
  • Recombinant Proteins
  • Sarcoma, Kaposi / drug therapy
  • Skin Diseases, Vesiculobullous / chemically induced*
  • Skin Diseases, Vesiculobullous / immunology

Substances

  • Antineoplastic Agents
  • Immunoglobulin A
  • Interferon alpha-2
  • Interferon-alpha
  • Recombinant Proteins