A novel approach to predict protein-protein interactions related to Alzheimer's disease based on complex network

Protein Pept Lett. 2010 Mar;17(3):356-66. doi: 10.2174/092986610790780323.

Abstract

A protein domain interaction prediction program was complied using C(++) to predict whether a query protein could interact with other hub proteins. It is indicated that the proteins interacting with AATF (Apoptosis-Antagonizing Transcription Factor) possess a common conservative pattern: I-x(0,1)-E-x(2)-[A/E/N/T]-x-[E/K]. Our method is attempted to integrate the characteristics of protein interaction network with the simplest building blocks-conservative patterns.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Alzheimer Disease / metabolism*
  • Amino Acid Sequence
  • Apoptosis Regulatory Proteins / metabolism
  • Computational Biology / methods*
  • Humans
  • Models, Statistical*
  • Molecular Sequence Data
  • Protein Interaction Mapping / methods*
  • Proteins / metabolism
  • Repressor Proteins / metabolism
  • Signal Transduction

Substances

  • AATF protein, human
  • Apoptosis Regulatory Proteins
  • Proteins
  • Repressor Proteins