[Studies on pyridonecarboxylic acids as anti-bacterial agents. IX. Study on prodrugs of some pyridonecarboxylic acids]

Z R Li; H Y Guo; Z P Zhang

[Studies on pyridonecarboxylic acids as anti-bacterial agents. IX. Study on prodrugs of some pyridonecarboxylic acids]

Yao Xue Xue Bao. 1991;26(2):111-6.

[Article in Chinese]

Authors

Z R Li¹, H Y Guo, Z P Zhang

Affiliation

¹ Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing.

PMID: 1950565

Abstract

Synthesis and antibacterial activity of pivaloyloxymethyl esters of norfloxacin, ciprofloxacin and their N-substituted derivatives are reported. In vivo antibacterial activities (ED50) of IIIAa, b, e; IIIBa, e; IVA and IVB were 2.30, 8.48, 4.28, 2.77, 4.46, 5.68 and 0.75 (mg/kg) respectively.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Infective Agents / chemical synthesis*
Ciprofloxacin / analogs & derivatives
Ciprofloxacin / chemical synthesis*
Escherichia coli Infections / drug therapy
Mice
Norfloxacin / analogs & derivatives
Norfloxacin / chemical synthesis*
Prodrugs / chemical synthesis*

Substances

Anti-Infective Agents
Prodrugs
Ciprofloxacin
Norfloxacin